Trifluoroacetic acid → HCID 58539653, compound

HRID 553752Notes

Reaction equation

C(OC([NH:8][C:9]1[C:10]([CH3:30])=[N:11][O:12][C:13]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][C:23]([CH2:26][C:27]([OH:29])=[O:28])=[CH:22][CH:21]=2)=[CH:16][CH:15]=1)=O)(C)(C)C.FC(F)(F)C(O)=O>>[NH2:8][C:9]1[C:10]([CH3:30])=[N:11][O:12][C:13]=1[C:14]1[CH:15]=[CH:16][C:17]([C:20]2[CH:25]=[CH:24][C:23]([CH2:26][C:27]([OH:29])=[O:28])=[CH:22][CH:21]=2)=[CH:18][CH:19]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 67351752HCID 67351752, compound

Product 1

HCID 58539653HCID 58539653, compound

Procedure

[4′-(4-tert-Butoxycarbonylamino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-acetic acid (1.0 mmol) was treated with trifluoroacetic acid (5 mL) for 1 hour. Work-up provided the title compound. Mass spec. data (M+H)=309.

Sources & evidence

ORD record: ord-c0c5676edae746f18b5b77e551ecd294
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08048902B2

Reaction notes

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