HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 553816Generated: October 27, 2026
Ethylene Glycol → 6-(2-Hydroxy-ethoxy)-2-phenyl-pyrimidine-4-carboxylic acid
https://huagongshe.com/reaction/553816
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 6-Chloro-2-phenylpyrimidine-4-carboxylic acid | HCID 57431698 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-(2-Hydroxy-ethoxy)-2-phenyl-pyrimidine-4-carboxylic acid | HCID 67462345 | — |
Reaction Steps
Ethylene glycol (34 μl) was added to a suspension of sodium hydride (24 mg) in anhydrous THF (2 ml) at 0° C. After 30 min stirring at 0° C., 6-chloro-2-phenyl-pyrimidine-4-carboxylic acid (47 mg) dissolved in THF (1.2 ml) was added. The mixture was allowed to warm to RT and stirred overnight. A 1M HCl solution was added and the resulting mixture was extracted with EA. The org. phases were dried (Na2SO4) and evaporated off.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08048881B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-94301cc1471848a0bfb7295c3e933394 |
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| Source note | uspto-grants-2011_11 |
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