反应详情

温度

0 °C

Ethylene glycol (34 μl) was added to a suspension of sodium hydride (24 mg) in anhydrous THF (2 ml) at 0° C. After 30 min stirring at 0° C., 6-chloro-2-phenyl-pyrimidine-4-carboxylic acid (47 mg) dissolved in THF (1.2 ml) was added. The mixture was allowed to warm to RT and stirred overnight. A 1M HCl solution was added and the resulting mixture was extracted with EA. The org. phases were dried (Na2SO4) and evaporated off.

1. additionwas added
2. temperatureto warm to RT
3. stirringstirred overnight
4. extractionthe resulting mixture was extracted with EA
5. dry with materialphases were dried (Na2SO4)
6. customevaporated off