HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 553824Generated: November 1, 2026
Water → 4-{(S)-4-tert-butoxycarbonyl-2-[(2-phenyl-6-propylamino-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester
https://huagongshe.com/reaction/553824
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Propylamine | HCID 7852 | — |
| Reactant | 4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester | HCID 86622404 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-{(S)-4-tert-butoxycarbonyl-2-[(2-phenyl-6-propylamino-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester | HCID 67459739 | — |
Reaction Steps
4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester (53 mg) and propylamine (31 μl) were dissolved in THF (0.5 ml). The mixture was stirred at 40° C. until reaction completion. Water was added and it was extracted with EA. The org. layers were dried (Na2SO4) and evaporated off to give 60 mg of the desired pure compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08048881B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-1e0225800fbd47919b13dbba38d3c7fb |
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| Source note | uspto-grants-2011_11 |
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