HRID553824

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID962

Water

H2O

HCID7852

Propylamine

C3H9N

HCID86622404

未命名化合物

PRODUCTS

产物

HCID67459739

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

CONDITIONS

反应条件

温度: 40 °C

PROCEDURE

实验过程

4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester (53 mg) and propylamine (31 μl) were dissolved in THF (0.5 ml). The mixture was stirred at 40° C. until reaction completion. Water was added and it was extracted with EA. The org. layers were dried (Na2SO4) and evaporated off to give 60 mg of the desired pure compound.

WORKUP

后处理

extractionit was extracted with EA
dry with materiallayers were dried (Na2SO4)
customevaporated off
customto give 60 mg of the desired pure compound

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-1e0225800fbd47919b13dbba38d3c7fb
来源数据集: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08048881B2
来源说明: uspto-grants-2011_11

反应SMILES

[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:39])[C@@H:13]([NH:23][C:24]([C:26]2[CH:31]=[C:30](Cl)[N:29]=[C:28]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[N:27]=2)=[O:25])[CH2:14][CH2:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:8][CH2:7]1)=[O:5])[CH3:2].[CH2:40]([NH2:43])[CH2:41][CH3:42].O>C1COCC1>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:39])[C@@H:13]([NH:23][C:24]([C:26]2[CH:31]=[C:30]([NH:43][CH2:40][CH2:41][CH3:42])[N:29]=[C:28]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[N:27]=2)=[O:25])[CH2:14][CH2:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:8][CH2:7]1)=[O:5])[CH3:2]