HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 553825Generated: October 31, 2026
Water → 4-((S)-4-tert-butoxycarbonyl-2-{[6-(ethoxycarbonylmethyl-amino)-2-phenyl-pyrimidine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester
https://huagongshe.com/reaction/553825
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Glycine ethyl ester, hydrochloride | HCID 2723640 | — |
| Reactant | 4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester | HCID 86622404 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-((S)-4-tert-butoxycarbonyl-2-{[6-(ethoxycarbonylmethyl-amino)-2-phenyl-pyrimidine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester | HCID 67461979 | — |
Reaction Steps
4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester (40 mg), glycine ethyl ester hydrochloride (23.8 mg) and NEt3 (20 l) were dissolved in THF (0.5 ml). The mixture was stirred at 40° C. until reaction completion. Water was added to the reaction mixture which was extracted with EA. The org. layers were dried (Na2SO4) and evaporated off to give 41 mg of the desired pure compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08048881B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-b392c9a29c4f4a05adc1c41a8a4a51cc |
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| Source note | uspto-grants-2011_11 |
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