HRID553825

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID962

Water

H2O

HCID8471

Triethylamine

C6H15N

HCID2723640

Ethyl glycinate hydrochloride

C4H10ClNO2

HCID86622404

未命名化合物

PRODUCTS

产物

HCID67461979

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

CONDITIONS

反应条件

温度: 40 °C

PROCEDURE

实验过程

4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester (40 mg), glycine ethyl ester hydrochloride (23.8 mg) and NEt3 (20 l) were dissolved in THF (0.5 ml). The mixture was stirred at 40° C. until reaction completion. Water was added to the reaction mixture which was extracted with EA. The org. layers were dried (Na2SO4) and evaporated off to give 41 mg of the desired pure compound.

WORKUP

后处理

extractionwas extracted with EA
dry with materiallayers were dried (Na2SO4)
customevaporated off
customto give 41 mg of the desired pure compound

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-b392c9a29c4f4a05adc1c41a8a4a51cc
来源数据集: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08048881B2
来源说明: uspto-grants-2011_11

反应SMILES

[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:39])[C@@H:13]([NH:23][C:24]([C:26]2[CH:31]=[C:30](Cl)[N:29]=[C:28]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[N:27]=2)=[O:25])[CH2:14][CH2:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:8][CH2:7]1)=[O:5])[CH3:2].Cl.[CH2:41]([O:43][C:44](=[O:47])[CH2:45][NH2:46])[CH3:42].CCN(CC)CC.O>C1COCC1>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:39])[C@@H:13]([NH:23][C:24]([C:26]2[CH:31]=[C:30]([NH:46][CH2:45][C:44]([O:43][CH2:41][CH3:42])=[O:47])[N:29]=[C:28]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[N:27]=2)=[O:25])[CH2:14][CH2:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:8][CH2:7]1)=[O:5])[CH3:2]