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Potassium Phosphate, Tribasic → Methyl 6-methyl-2-phenylpyrimidine-4-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 反応物 | Phenylboronic Acid | HCID 66827 | — |
| 反応物 | Methyl 2-chloro-6-methylpyrimidine-4-carboxylate | HCID 2736835 | — |
| 反応物 | Water ethylacetate | HCID 22728543 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | Methyl 6-methyl-2-phenylpyrimidine-4-carboxylate | HCID 58101529 | — |
反応手順
2-chloro-6-methyl-pyrimidine-4-carboxylic acid methyl ester (930 mg), phenylboronic acid (610 mg), tetrakis(triphenylphosphine)palladium (265 mg) and potassium phosphate (2.12 g) were dissolved in anhydrous dioxane (25 ml) under argon. The mixture was refluxed overnight and worked up with water/EA. The org. phases were dried (Na2SO4) and evaporated off. Column chromatography (EA/Hept 1/5) offered 875 mg of the desired compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08048881B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-99a308eb50b24b91a6980a55a346e494 |
| 出典メモ | uspto-grants-2011_11 |