HCID 69076198, compound → HCID 69077797, compound

HRID 553874Notes

Reaction equation

HRID 553874 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:16][CH2:15][CH2:14][C@@H:13]3[N:9]2[C:10](=[O:17])[CH:11]=[CH:12]3)=[CH:4][CH:3]=1.[H][H]>CO.[Pt]=O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:16][CH2:15][CH2:14][C@@H:13]3[N:9]2[C:10](=[O:17])[CH2:11][CH2:12]3)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 69076198HCID 69076198, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 69077797HCID 69077797, compoundYield 82.1%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

Platinum oxide (10 mg) was added to a solution of (5R*,8aS*)-5-(4-fluorophenyl)-6,7,8,8a-tetrahydro-5H-indolizin-3-one (105 mg) in methanol (5 mL), and the reaction solution was stirred in a hydrogen stream at room temperature for three hours. The reaction solution was filtered through celite, and the filtrate was concentrated under reduced pressure to obtain 87 mg of the title compound. The property value of the compound is as follows.

Workup

  1. filtrationThe reaction solution was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-611041b2f3184802b18c1107e970abae
Source dataset
uspto-grants-2011_11
Patent number
US08048878B2

Reaction notes

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