Triethyl phosphite → HCID 86612696, compound

HRID 553876Notes

Reaction equation

HRID 553876 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[CH2:16][CH2:15][CH2:14][C@H:13]3[N:9]2[C:10](=[O:18])[CH:11](I)[CH2:12]3)=[CH:4][CH:3]=1.[P:19]([O:26]CC)([O:23][CH2:24][CH3:25])[O:20][CH2:21][CH3:22]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[CH2:16][CH2:15][CH2:14][C@H:13]3[N:9]2[C:10](=[O:18])[CH:11]([P:19](=[O:26])([O:23][CH2:24][CH3:25])[O:20][CH2:21][CH3:22])[CH2:12]3)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 31215Triethyl phosphiteHCID 69077078HCID 69077078, compound

Product 1

HCID 86612696HCID 86612696, compound

Conditions

Temperature
120 °C

Procedure

A mixture of (5S*,8aR*)-5-(4-fluorophenyl)-2-iodohexahydroindolizin-3-one (120 mg) with triethyl phosphite (2 mL) was stirred at 120° C. for 14 hours. The reaction solution was left to cool to room temperature and then concentrated under reduced pressure to obtain 123 mg of the title compound. The property value of the compound is as follows.

Workup

  1. waitThe reaction solution was left
  2. temperatureto cool to room temperature
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-b3839a51533148958edb713d6932f2c3
Source dataset
uspto-grants-2011_11
Patent number
US08048878B2

Reaction notes

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