HCID 67463031, compound → HCID 67460105, compound

HRID 553975Notes

Reaction equation

HRID 553975 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1[C@H:10]1[N:18]2[C@@H:13]([CH:14]=[CH:15][CH2:16][C:17]2=[O:19])[CH2:12][CH2:11]1.[H][H]>CO.[Pt]=O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1[C@H:10]1[N:18]2[C@H:13]([CH2:14][CH2:15][CH2:16][C:17]2=[O:19])[CH2:12][CH2:11]1

Participants

5

Reactant 2

HCID 67463031HCID 67463031, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67460105HCID 67460105, compoundYield 99.6%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

Platinum oxide (25 mg) was added to a solution of (3S,8aR)-3-(2,4,6-trifluorophenyl)-2,3,6,8a-tetrahydro-1H-indolizin-5-one (548 mg) in methanol (5 mL), and the reaction solution was stirred in a hydrogen atmosphere at 1 atm at room temperature for one hour. The reaction solution was filtered through celite, and the filtrate was concentrated under reduced pressure to obtain 550 mg of the title compound. The property value of the compound is as follows.

Workup

  1. filtrationThe reaction solution was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-f0b49e79cd9541f6a0dae8b893f9b966
Source dataset
uspto-grants-2011_11
Patent number
US08048878B2

Reaction notes

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