Diethylamine → Methyl 3-(2-ethoxycarbonylvinyl)-5-(3,4,5-trifluorophenyl)piperazine-1-carboxylate

HRID 554006노트

반응식

HRID 554006 반응식
C(NCC)C.[CH3:6][O:7][C:8]([N:10]1[CH2:15][CH:14]([C:16]2[CH:21]=[C:20]([F:22])[C:19]([F:23])=[C:18]([F:24])[CH:17]=2)[N:13](C(OCC2C3C=CC=CC=3C3C2=CC=CC=3)=O)[CH:12]([CH:42]=[CH:43][C:44]([O:46][CH2:47][CH3:48])=[O:45])[CH2:11]1)=[O:9]>C(#N)C>[CH2:47]([O:46][C:44]([CH:43]=[CH:42][CH:12]1[NH:13][CH:14]([C:16]2[CH:21]=[C:20]([F:22])[C:19]([F:23])=[C:18]([F:24])[CH:17]=2)[CH2:15][N:10]([C:8]([O:7][CH3:6])=[O:9])[CH2:11]1)=[O:45])[CH3:48]

참가 물질

4

반응물 2

HCID 8021DiethylamineHCID 67460768HCID 67460768, 화합물

생성물 1

HCID 67464101Methyl 3-(2-ethoxycarbonylvinyl)-5-(3,4,5-trifluorophenyl)piperazine-1-carboxylate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Diethylamine (2 mL) was added to a solution of 2-(2-ethoxycarbonylvinyl)-6-(3,4,5-trifluorophenyl)piperazine-1,4-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester 4-methyl ester (1.03 g) in acetonitrile (10 mL), and the reaction solution was stirred at room temperature for one hour. The reaction solution was concentrated, and the residue was purified by silica gel column chromatography (heptane->ethyl acetate) to obtain 422 mg of an E/Z isomer mixture of the title compound. The property value of the compound is as follows.

후처리

  1. concentrationThe reaction solution was concentrated
  2. customthe residue was purified by silica gel column chromatography (heptane->ethyl acetate)
  3. customto obtain

출처 및 근거

ORD 기록
ord-0fe97f69f1be4f8493f5484152280e3d
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08048878B2

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