反应详情

温度

60 °C

A mixture of 1.5 g of (3aRS,4RS,5RS,7aSR)-2-benzyl-4-(2-methoxyphenyl)-4,5-perhydroisoindolediol and 120 cm3 of anhydrous ethanol is heated to 60° C. with stirring; 0.49 g of 20% palladium hydroxide on charcoal is added and the reaction mixture is then hydrogenated, with stirring, at a temperature of 60° C. and at atmospheric pressure. After reaction for 2 hours, the theoretical volume of hydrogen has been absorbed; the reaction mixture is filtered and then concentrated to dryness under reduced pressure (2.7 kPa). The residue is crystallized in 50 cm3 of isopropyl ether. 1.02 g of (3aRS,4RS,5RS,7aSR)-4-(2-methoxyphenyl)-4,5-perhydroisoindolediol are obtained, melting at 168° C.

1. stirringhydrogenated, with stirring, at a temperature of 60° C. and at atmospheric pressure
2. customAfter reaction for 2 hours
3. customthe theoretical volume of hydrogen has been absorbed
4. filtrationthe reaction mixture is filtered
5. concentrationconcentrated to dryness under reduced pressure (2.7 kPa)
6. customThe residue is crystallized in 50 cm3 of isopropyl ether