Hydrochloric Acid → HCID 87409351, compound

HRID 554021Notes

Reaction equation

HRID 554021 reaction equation
[CH2:1]1[CH:5]([CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])[S:4][S:3][CH2:2]1.[Zn:13].Cl>CO>[Zn:13].[SH:4][CH:5]([CH2:1][CH2:2][SH:3])[CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 864alpha Lipoic acidHCID 23994Zinc

Product 1

HCID 87409351HCID 87409351, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

6.2 g of DL-α-lipoic acid was dissolved in 70 ml of methanol, and to this were added 3.5 g of zinc powder and 15 ml of 2 N hydrochloric acid and stirred for one hour at 50° C. When the solution turned colorless, unreacted zinc was removed by filtration, and the filtrate was concentrated under reduced pressure. Addition of 150 ml of water to the oily residue, collection of thus precipitated white crystals by filtration and washing with water gave the free acid form of 6,8-dimercaptooctanoic acid zinc chelate compound.

Workup

  1. customunreacted zinc was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. additionAddition of 150 ml of water
  4. customto the oily residue, collection of thus precipitated white crystals
  5. filtrationby filtration
  6. washwashing with water

Sources & evidence

ORD record
ord-1e110e13b1784bb5adaa66c16293aa32
Source dataset
uspto-grants-2011_11
Patent number
US08048911B2

Reaction notes

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