1,4-Dioxane → HCID 67460134, compound

HRID 554089Notes

Reaction equation

HRID 554089 reaction equation
C[C:2]1([C:22]([O-:24])=[O:23])[CH2:6][CH:5]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:4](=[O:14])[N:3]1C(OC(C)(C)C)=O.O1CCOC[CH2:26]1>Cl>[CH3:26][O:24][C:22](=[O:23])[C@@H:2]1[CH2:6][CH:5]([CH2:7][C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:4](=[O:14])[NH:3]1

Participants

4

Reactant 2

HCID 312751,4-DioxaneHCID 131728127HCID 131728127, compound

Product 1

HCID 67460134HCID 67460134, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

1-(1,1-Dimethylethyl) 2-methyl-5-oxo-4-(phenylmethyl)-1,2-pyrrolidinedicarboxylate (0.415 g, 1.24 mmol) was dissolved in 4M hydrogen chloride in dioxane (2 ml) and stirred at room temperature for 2 hrs. The solvent was evaporated to give a colourless oil which crystallized on standing to give methyl-5-oxo-4-(phenylmethyl)-prolinate as a creamy/white solid (0.205 g). This was used without further purification in the next step.

Workup

  1. customThe solvent was evaporated
  2. customto give a colourless oil which
  3. customcrystallized

Sources & evidence

ORD record
ord-6deb1dad52b9482dad8f20a5d3b380b2
Source dataset
uspto-grants-2011_11
Patent number
US08048907B2

Reaction notes

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