HCID 67458808, compound → HCID 67462825, compound

HRID 554094Notes

Reaction equation

HRID 554094 reaction equation
[CH3:1][C:2](=[CH2:17])[CH2:3][N:4]1[C:15](=[O:16])[CH2:14][CH2:13][C@H:5]1[C:6]([O:8]C(C)(C)C)=[O:7]>ClCCl.FC(F)(F)C(O)=O>[CH3:17][C:2](=[CH2:1])[CH2:3][N:4]1[C:15](=[O:16])[CH2:14][CH2:13][C@H:5]1[C:6]([OH:8])=[O:7]

Participants

4

Reactant 1

HCID 67458808HCID 67458808, compound

Product 1

HCID 67462825HCID 67462825, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

1,1-dimethylethyl 1-(2-methyl-2-propen-1-yl)-5-oxoprolinate (0.099 g, 0.41 mmol) was dissolved in a mixture of dichloromethane (2 ml) and trifluoroacetic acid (2 ml) and stirred overnight at room temperature. The solvent was evaporated (azeotroping with toluene to remove traces of trifluoroacetic acid) to give crude 1-(2-methyl-2-propen-1-yl)-5-oxoproline as a brown oil which was used without further purification.

Workup

  1. customThe solvent was evaporated
  2. custom(azeotroping with toluene to remove traces of trifluoroacetic acid)

Sources & evidence

ORD record
ord-f35389fe6d394e9883d28991f30deba3
Source dataset
uspto-grants-2011_11
Patent number
US08048907B2

Reaction notes

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