2,4-Dichlorobenzylamine → N-[(2,4-dichlorophenyl)methyl]-5-oxo-1-(3-pyridinylmethyl)prolinamide

HRID 554141Notes

Reaction equation

HRID 554141 reaction equation
[Cl:1][C:2]1[C:7](C(F)(F)F)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:12][NH:13][C:14](=[O:28])[C@@H:15]1[CH2:19][CH2:18][C:17](=[O:20])[N:16]1[CH2:21][C:22]1[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=1.[Cl:29]C1C=C(Cl)C=CC=1CN>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:29])[CH:5]=[CH:4][C:3]=1[CH2:12][NH:13][C:14](=[O:28])[C@@H:15]1[CH2:19][CH2:18][C:17](=[O:20])[N:16]1[CH2:21][C:22]1[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 14852,4-DichlorobenzylamineHCID 67459890N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-5-oxo-1-(3-pyridinylmethyl)prolinamide

Product 1

HCID 67462337N-[(2,4-dichlorophenyl)methyl]-5-oxo-1-(3-pyridinylmethyl)prolinamide

Procedure

N-[(2,4-dichlorophenyl)methyl]-5-oxo-1-(3-pyridinylmethyl)prolinamide was prepared in a manner analogous to that described above for the synthesis of N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-5-oxo-1-(3-pyridinylmethyl)prolinamide (E120) but using [(2,4-dichlorophenyl)methyl]amine in the place of {[2-chloro-3-(trifluoromethyl)phenyl]methyl}amine.

Sources & evidence

ORD record
ord-d77667629eef4e26a1db661d1976acec
Source dataset
uspto-grants-2011_11
Patent number
US08048907B2

Reaction notes

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