Methyl morpholine oxide → HCID 86232916, compound

HRID 554166Notes

Reaction equation

HRID 554166 reaction equation
[CH3:1][S:2]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:8][C:7]([CH2:16][OH:17])=[CH:6]1)(=[O:4])=[O:3].C[N+]1([O-])CCOCC1>[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[CH3:1][S:2]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:8][C:7]([CH:16]=[O:17])=[CH:6]1)(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 82029Methyl morpholine oxideHCID 66924669HCID 66924669, compound

Product 1

HCID 86232916HCID 86232916, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 178419074HCID 178419074, compoundCatalyst

Procedure

Using [1-(methylsulfonyl)-5-phenyl-1H-pyrrol-3-yl]methanol (220 mg), tetra-n-propylammonium perruthenate (31 mg), N-methylmorpholine N-oxide (177 mg) and molecular sieves 4A powder (500 mg), a procedure as in Reference Example 6 was performed to give the title compound as a brown oil (yield 165 mg, 76%).

Sources & evidence

ORD record
ord-c364dee6c0db4ecca4e7b21892ce03a4
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

Loading…