反应详情

温度

60 °C

To a solution of I g of (3aRS,4RS,5RS,7aSR)-2-benzyl-4-(2-methoxyphenyl)-5-methyl-4-perhydroisoindolol in 15 cm3 of anhydrous ethanol are added 2 g of 20% palladium hydroxide on charcoal and the reaction mixture is then hydrogenated, with stirring, at a temperature of 60° C. and at atmospheric pressure. After reaction for 1 hour, the reaction mixture is filtered and then concentrated to dryness under reduced pressure (2.7 kPa). 0.74 g of (3aRS,4RS, 5RS, 7aSR)-4-(2-methoxyphenyl)-5-methyl-4-perhydroisoindolol is obtained in the form of a yellow foam.

1. customAfter reaction for 1 hour
2. filtrationthe reaction mixture is filtered
3. concentrationconcentrated to dryness under reduced pressure (2.7 kPa)