Benzenesulfonyl chloride → HCID 66924955, compound

HRID 554238Notes

Reaction equation

HRID 554238 reaction equation
[H-].[Na+].[Br:3][C:4]1[NH:8][CH:7]=[C:6]([C:9]([O:11][CH2:12]C)=[O:10])[C:5]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[C:20]1([S:26](Cl)(=[O:28])=[O:27])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[Br:3][C:4]1[N:8]([S:26]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)(=[O:28])=[O:27])[CH:7]=[C:6]([C:9]([O:11][CH3:12])=[O:10])[C:5]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 3

HCID 7369Benzenesulfonyl chlorideHCID 24758Sodium hydrideHCID 66924635HCID 66924635, compound

Product 1

HCID 66924955HCID 66924955, compoundYield 93%

Procedure

Using sodium hydride (60% in oil, 281 mg), ethyl 5-bromo-4-phenyl-1H-pyrrole-3-carboxylate (1.70 g) and benzenesulfonyl chloride (0.9 mL), a procedure as in Reference Example 41 was performed to give the title compound as white crystals (yield 2.51 g, 93%).

Sources & evidence

ORD record
ord-582faf0ab33149dc8ebbe94723d2adb8
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

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