Methyl morpholine oxide → HCID 86232752, compound

HRID 554242Notes

Reaction equation

HRID 554242 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:12][CH:11]=[C:10]([CH2:13][OH:14])[C:9]=1[CH3:15].C[N+]1([O-])CCOCC1>[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:12][CH:11]=[C:10]([CH:13]=[O:14])[C:9]=1[CH3:15]

Participants

4

Reactant 2

HCID 82029Methyl morpholine oxideHCID 66924472HCID 66924472, compound

Product 1

HCID 86232752HCID 86232752, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 178419074HCID 178419074, compoundCatalyst

Procedure

Using [5-(2-fluorophenyl)-4-methyl-1H-pyrrol-3-yl]methanol (1.17 g), tetra-n-propylammonium perruthenate (101 mg), N-methylmorpholine N-oxide (1.01 g) and molecular sieves 4A powder (572 mg), a procedure as in Reference Example 65 was performed to give the title compound as pale-pink crystals (yield 0.67 g, 58%).

Sources & evidence

ORD record
ord-3727dc02e0a247f2a54cea3ecf5502b4
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

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