Benzenesulfonyl chloride → HCID 66924911, compound

HRID 554268Notes

Reaction equation

HRID 554268 reaction equation
[CH3:1][C:2]1[NH:3][C:4]([C:12]2[CH:16]=[CH:15][S:14][CH:13]=2)=[CH:5][C:6]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8].[H-].[Na+].[C:19]1([S:25](Cl)(=[O:27])=[O:26])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH3:1][C:2]1[N:3]([S:25]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)(=[O:27])=[O:26])[C:4]([C:12]2[CH:16]=[CH:15][S:14][CH:13]=2)=[CH:5][C:6]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8]

Participants

4

Reactant 3

HCID 7369Benzenesulfonyl chlorideHCID 24758Sodium hydrideHCID 66924664HCID 66924664, compound

Product 1

HCID 66924911HCID 66924911, compoundYield 40%

Procedure

Using ethyl 2-methyl-5-(3-thienyl)-1H-pyrrole-3-carboxylate (1.25 g), sodium hydride (60% in oil, 255 mg) and benzenesulfonyl chloride (1.22 mL), a procedure as in Reference Example 4 was performed to give the title compound as white crystals (yield 0.80 g, 40%).

Sources & evidence

ORD record
ord-c5b0497d66ab4d78b7d0e1c5e9c53d0e
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

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