Benzenesulfonyl chloride → HCID 66924727, compound

HRID 554271Notes

Reaction equation

HRID 554271 reaction equation
[C:1]1([C:7]2[C:8]([C:18]([O:20][CH3:21])=[O:19])=[CH:9][NH:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].[C:24]1([S:30](Cl)(=[O:32])=[O:31])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[C:1]1([C:7]2[C:8]([C:18]([O:20][CH3:21])=[O:19])=[CH:9][N:10]([S:30]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)(=[O:32])=[O:31])[C:11]=2[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 7369Benzenesulfonyl chlorideHCID 24758Sodium hydrideHCID 15274277HCID 15274277, compound

Product 1

HCID 66924727HCID 66924727, compoundYield 79%

Procedure

Using methyl 4,5-diphenyl-1H-pyrrole-3-carboxylate (428 mg), sodium hydride (60% in oil, 74 mg) and benzenesulfonyl chloride (0.24 mL), a procedure as in Reference Example 4 was performed to give the title compound as white crystals (yield 506 mg, 79%).

Sources & evidence

ORD record
ord-253b6e44aa6d4a8088afecc32c0af01d
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

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