Diisobutylaluminumhydride → HCID 66924627, compound

HRID 554289Notes

Reaction equation

HRID 554289 reaction equation
[CH3:1][C:2]1[N:3]([S:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)(=[O:18])=[O:17])[C:4]([C:11]2[CH:15]=[CH:14][S:13][CH:12]=2)=[CH:5][C:6]=1[C:7](OC)=[O:8].[H-].C([Al+]CC(C)C)C(C)C>C1(C)C=CC=CC=1>[CH3:1][C:2]1[N:3]([S:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)(=[O:17])=[O:18])[C:4]([C:11]2[CH:15]=[CH:14][S:13][CH:12]=2)=[CH:5][C:6]=1[CH2:7][OH:8]

Participants

4

Reactant 2

HCID 21225700DiisobutylaluminumhydrideHCID 66925021HCID 66925021, compound

Product 1

HCID 66924627HCID 66924627, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Using methyl 2-methyl-1-(phenylsulfonyl)-5-(3-thienyl)-1H-pyrrole-3-carboxylate (0.75 g) and a 1.5 mol/L solution (4.0 mL) of diisobutylaluminum hydride in toluene, a procedure as in Reference Example 5 was performed to give the title compound as a brown oil (yield 0.42 g, 63%).

Sources & evidence

ORD record
ord-50e7336468cf4fed9bcefc20c3ff260a
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

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