Diisobutylaluminumhydride → HCID 66924715, compound

HRID 554291Notes

Reaction equation

HRID 554291 reaction equation
[CH3:1][C:2]1[N:3]([S:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)(=[O:21])=[O:20])[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:5]([CH3:12])[C:6]=1[C:7](OCC)=[O:8].[H-].C([Al+]CC(C)C)C(C)C>C1(C)C=CC=CC=1>[CH3:1][C:2]1[N:3]([S:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)(=[O:21])=[O:20])[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:5]([CH3:12])[C:6]=1[CH2:7][OH:8]

Participants

4

Reactant 2

HCID 21225700DiisobutylaluminumhydrideHCID 66924705HCID 66924705, compound

Product 1

HCID 66924715HCID 66924715, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Using ethyl 2,4-dimethyl-5-phenyl-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate (1.01 g) and a 1.5 mol/L solution (6.0 mL) of diisobutylaluminum hydride in toluene, a procedure as in Reference Example 5 was performed to give the title compound as a brown oil (yield 0.84 g, 94%).

Sources & evidence

ORD record
ord-c6f979b7b802448d96c8d6c577e75ce3
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

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