Diisobutylaluminumhydride → HCID 66924614, compound

HRID 554293Notes

Reaction equation

HRID 554293 reaction equation
[C:1]1([C:7]2[C:8]([C:27](OC)=[O:28])=[CH:9][N:10]([S:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)(=[O:20])=[O:19])[C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].C([Al+]CC(C)C)C(C)C>C1(C)C=CC=CC=1>[C:1]1([C:7]2[C:8]([CH2:27][OH:28])=[CH:9][N:10]([S:18]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)(=[O:19])=[O:20])[C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 21225700DiisobutylaluminumhydrideHCID 66924727HCID 66924727, compound

Product 1

HCID 66924614HCID 66924614, compoundYield 88.1%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Using methyl 4,5-diphenyl-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate (439 mg) and a 1.5 mol/L solution (3.2 mL) of diisobutylaluminum hydride in toluene, a procedure as in Reference Example 5 was performed to give the title compound as a brown oil (yield 361 mg, 88%).

Sources & evidence

ORD record
ord-50c7b98d88ea47f6a272090e337725cd
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

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