Methyl morpholine oxide → HCID 86232871, compound

HRID 554308Notes

Reaction equation

HRID 554308 reaction equation
[C:1]1([C:7]2[C:8]([CH2:27][OH:28])=[CH:9][N:10]([S:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)(=[O:20])=[O:19])[C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[N+]1([O-])CCOCC1>[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[C:1]1([C:7]2[C:8]([CH:27]=[O:28])=[CH:9][N:10]([S:18]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)(=[O:19])=[O:20])[C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 82029Methyl morpholine oxideHCID 66924614HCID 66924614, compound

Product 1

HCID 86232871HCID 86232871, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 178419074HCID 178419074, compoundCatalyst

Procedure

Using [4,5-diphenyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methanol (352 mg), tetra-n-propylammonium perruthenate (13.8 mg), N-methylmorpholine N-oxide (159 mg) and molecular sieves 4A powder (177 mg), a procedure as in Reference Example 6 was performed to give the title compound as white crystals (yield 250 mg, 72%).

Sources & evidence

ORD record
ord-bc31bbffd7d94f5bb9ec6b568a02df73
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

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