Hydrochloric Acid → HCID 67714375, compound

HRID 55431Notes

Reaction equation

HRID 55431 reaction equation
[CH3:1][C:2]1([CH3:17])[CH:10]2[CH:6]([CH2:7][N:8](C(OC=C)=O)[CH2:9]2)[C:5](=[O:16])[CH:4]=[CH:3]1.[ClH:18]>>[ClH:18].[CH3:1][C:2]1([CH3:17])[CH:10]2[CH:6]([CH2:7][NH:8][CH2:9]2)[C:5](=[O:16])[CH:4]=[CH:3]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67714078HCID 67714078, compound

Product 1

HCID 67714375HCID 67714375, compound

Procedure

A solution of 5.83 g of (3aRS,7aRS)-7,7-dimethyl-2-vinyloxycarbonyl-2,3,3a,4,7,7a-hexahydro-1H-4-isoindolone in 80 cm3 of hydrochloric acid-saturated dioxane is stirred at room temperature for 1 hour and then concentrated to dryness under reduced pressure (2.5 kPa). The residue is dissolved in 150 cm3 of ethanol and the solution is brought to reflux for 1 hour 30 minutes and is then concentrated to dryness under reduced pressure (2.5 kPa). 5.2 g of (3aRS,7aRS)7,7-dimethyl-2,3,3a,4,7,7a-hexahydro-1H-4-isoindolone hydrochloride are obtained in the form of a brown foam.

Workup

  1. concentrationconcentrated to dryness under reduced pressure (2.5 kPa)
  2. dissolutionThe residue is dissolved in 150 cm3 of ethanol
  3. temperatureto reflux for 1 hour 30 minutes
  4. concentrationis then concentrated to dryness under reduced pressure (2.5 kPa)

Sources & evidence

ORD record
ord-ce1305f07f304455b68d2712b39b58a3
Source dataset
uspto-grants-1997_04
Patent number
US05624950

Reaction notes

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