Sodium borohydride → HCID 66924687, compound

HRID 554424Notes

Reaction equation

HRID 554424 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([S:10]([N:13]2[CH:17]=[C:16]([CH:18]=O)[CH:15]=[C:14]2[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)(=[O:12])=[O:11])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].CO.[CH3:28][NH2:29].[BH4-].[Na+]>>[ClH:1].[Cl:1][C:2]1[CH:9]=[C:8]([S:10]([N:13]2[CH:17]=[C:16]([CH2:18][NH:29][CH3:28])[CH:15]=[C:14]2[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)(=[O:12])=[O:11])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Participants

4

Reactant 3

HCID 4311764Sodium borohydrideHCID 57454252Monomethylamine methanolHCID 86620779HCID 86620779, compound

Product 1

HCID 66924687HCID 66924687, compoundYield 24%

Procedure

Using 2-chloro-4-[(4-formyl-2-phenyl-1H-pyrrol-1-yl)sulfonyl]benzonitrile (248 mg), 40% methylamine methanol solution (1.4 mL) and sodium borohydride (28.9 mg), a procedure as in Example 9 was performed to give the title compound as white crystals (yield 67.8 mg, 24%).

Sources & evidence

ORD record
ord-abc622816934403e8ab644cc0dea0cbf
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

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