Hydrogen chloride-ethyl acetate → HCID 66925289, compound

HRID 554451Notes

Reaction equation

HRID 554451 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]2[C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:15][C:14]([CH2:23][NH:24][C:25](=O)OC(C)(C)C)=[CH:13]2)(=[O:11])=[O:10])=[CH:5][C:4]=1[F:32])#[N:2].C(OCC)(=O)C.[ClH:39]>>[ClH:39].[F:32][C:4]1[CH:5]=[C:6]([S:9]([N:12]2[CH:13]=[C:14]([CH2:23][NH:24][CH3:25])[CH:15]=[C:16]2[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)(=[O:11])=[O:10])[CH:7]=[CH:8][C:3]=1[C:1]#[N:2]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86620792HCID 86620792, compound

Product 1

HCID 66925289HCID 66925289, compoundYield 14%

Procedure

Using tert-butyl ({1-[(4-cyano-3-fluorophenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)carbamate (54.7 mg) and 4 mol/L hydrogen chloride-ethyl acetate solution (4 mL), a procedure as in Example 30 was performed to give the title compound as a white solid (yield 6.9 mg, 14%).

Sources & evidence

ORD record
ord-af40db080fdf41e1893e06bf2369a22f
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

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