反应详情

温度

60 °C

Tenofovir disoproxil fumarate (100 gms, 0.1574 moles) is suspended in Isopropyl alcohol (1100 ml) at 25-35° C. The suspension is heated to about 60° C. for clear solution. The obtained clear solution is maintained for 1 hr at 60-65° C. Slowly cooled the mass to 30° C. in 1 hr and again cooled to 8° C. and maintained for ½ hr at 8-10° C. The precipitated product is filtered and washed with chilled Isopropanol. The wet material is dried at 50-55° C. under vacuum to give Tenofovir disoproxil hemifumarate.

1. temperatureThe obtained clear solution is maintained for 1 hr at 60-65° C
2. temperatureSlowly cooled the mass to 30° C. in 1 hr
3. temperatureagain cooled to 8° C.
4. temperaturemaintained for ½ hr at 8-10° C
5. filtrationThe precipitated product is filtered
6. washwashed with chilled Isopropanol
7. customThe wet material is dried at 50-55° C. under vacuum