HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → Tenofovir Disoproxil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Tenofovir Disoproxil Fumarate | HCID 6398764 | — |
| Solvent | Water | HCID 962 | — |
| Product | Tenofovir Disoproxil | HCID 5481350 | — |
Reaction Steps
Tenofovir disoproxil fumarate (100 gms, 0.1574 moles) is suspended in DM water (500 ml) and ethyl acetate (500 ml) at 25-35° C. and adjusted pH to neutral with saturated Sodium bicarbonate solution. Reaction mixture is settled and the separated ethyl acetate layer is evaporated under vacuum below 45° C. to get Tenofovir disoproxil as residue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08049009B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-9549087e0951430caff50047e7af3f9e |
| Source note | uspto-grants-2011_11 |