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HRID554466

反应详情

EQUATION

反应方程式

HRID 554466 的结构方程式

REACTANTS

反应物

3
结构：CCOC(C)=O
HCID8857

Ethyl acetate

C4H8O2

结构：O=C([O-])O.[Na+]
HCID516892

Sodium Bicarbonate

CHNaO3

结构：CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc21)OCOC(=O)OC(C)C.O=C(O)/C=C/C(=O)O
HCID6398764

Tenofovir disoproxil fumarate

C23H34N5O14P

PRODUCTS

生成物

1
结构：CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc21)OCOC(=O)OC(C)C
HCID5481350

Tenofovir disoproxil

C19H30N5O10P

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

Tenofovir disoproxil fumarate (100 gms, 0.1574 moles) is suspended in DM water (500 ml) and ethyl acetate (500 ml) at 25-35° C. and adjusted pH to neutral with saturated Sodium bicarbonate solution. Reaction mixture is settled and the separated ethyl acetate layer is evaporated under vacuum below 45° C. to get Tenofovir disoproxil as residue.

WORKUP

后处理

  1. customat 25-35° C.
  2. customReaction mixture
  3. customthe separated ethyl acetate layer is evaporated under vacuum below 45° C.