4-Chlorophenol → 9-(4-Chlorophenoxy)-3-azaspiro[5.5]undecane

HRID 554473Notes

Reaction equation

HRID 554473 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(OC([N:16]1[CH2:21][CH2:20][C:19]2([CH2:26][CH2:25][CH:24](O)[CH2:23][CH2:22]2)[CH2:18][CH2:17]1)=O)(C)(C)C>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH:24]2[CH2:25][CH2:26][C:19]3([CH2:20][CH2:21][NH:16][CH2:17][CH2:18]3)[CH2:22][CH2:23]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 46844-ChlorophenolHCID 66701044tert-Butyl 9-hydroxy-3-azaspiro[5.5]undecane-3-carboxylate

Product 1

HCID 160065449-(4-Chlorophenoxy)-3-azaspiro[5.5]undecane

Procedure

Was prepared according to method A from 4-chlorophenol and 9-hydroxy-3-aza-spiro[5.5]undecane-3-carboxylic acid tert-butyl ester. Mp. 140-142° C.

Workup

  1. customWas prepared

Sources & evidence

ORD record
ord-ed896ae0a6674ac4944d60617d5616aa
Source dataset
uspto-grants-2011_11
Patent number
US08049012B2

Reaction notes

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