2-Naphthol → 9-[(Naphthalen-2-yl)oxy]-3-azaspiro[5.5]undecane

HRID 554474Notes

Reaction equation

HRID 554474 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[OH:11].C(OC([N:19]1[CH2:24][CH2:23][C:22]2([CH2:29][CH2:28][CH:27](O)[CH2:26][CH2:25]2)[CH2:21][CH2:20]1)=O)(C)(C)C>>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH:27]1[CH2:28][CH2:29][C:22]2([CH2:23][CH2:24][NH:19][CH2:20][CH2:21]2)[CH2:25][CH2:26]1

Participants

3

Reactant 2

HCID 86632-NaphtholHCID 66701044tert-Butyl 9-hydroxy-3-azaspiro[5.5]undecane-3-carboxylate

Product 1

HCID 160065489-[(Naphthalen-2-yl)oxy]-3-azaspiro[5.5]undecane

Procedure

Was prepared according to method A from 2-naphthol and 9-hydroxy-3-aza-spiro[5.5]undecane-3-carboxylic acid tert-butyl ester. Mp. 132.2-133.8° C.

Workup

  1. customWas prepared

Sources & evidence

ORD record
ord-ceecfeb43dd2495cb156cf98f6f4237f
Source dataset
uspto-grants-2011_11
Patent number
US08049012B2

Reaction notes

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