6-hydroxy-2H-chromen-2-one → 6-(3-Aza-spiro[5.5]undec-9-yloxy)-chromen-2-one

HRID 554475Notes

Reaction equation

HRID 554475 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][C:7](=[O:12])[CH:6]=[CH:5]2.C(OC([N:20]1[CH2:25][CH2:24][C:23]2([CH2:30][CH2:29][CH:28](O)[CH2:27][CH2:26]2)[CH2:22][CH2:21]1)=O)(C)(C)C>>[CH2:22]1[C:23]2([CH2:30][CH2:29][CH:28]([O:1][C:2]3[CH:3]=[C:4]4[C:9](=[CH:10][CH:11]=3)[O:8][C:7](=[O:12])[CH:6]=[CH:5]4)[CH2:27][CH2:26]2)[CH2:24][CH2:25][NH:20][CH2:21]1

Participants

3

Reactant 2

HCID 994776-hydroxy-2H-chromen-2-oneHCID 66701044tert-Butyl 9-hydroxy-3-azaspiro[5.5]undecane-3-carboxylate

Product 1

HCID 160065496-(3-Aza-spiro[5.5]undec-9-yloxy)-chromen-2-one

Procedure

Was prepared according to method A from 6-hydroxycoumarin and 9-hydroxy-3-aza-spiro[5.5]undecane-3-carboxylic acid tert-butyl ester. Mp. 192.9-193.6° C.

Workup

  1. customWas prepared

Sources & evidence

ORD record
ord-a28ddcbfa0d14798a690decd4a26cffc
Source dataset
uspto-grants-2011_11
Patent number
US08049012B2

Reaction notes

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