反应详情

137.76 g of (R)-2-hydroxy-3-methoxycarbonyl-2-penten-4-olide are dissolved in 660 ml of toluene and at -10° C. 110 g of methanesulphonyl chloride and then, within a period of 1 hour, 97 g of triethylamine, are added. 350 ml of water and 150 ml of saturated sodium chloride solution are added, the toluene product phase is removed and the aqueous phase is re-extracted twice with 250 ml of toluene. The toluene phases are washed with sodium chloride solution and with water and concentrated by evaporation. Orange-red oil, [α]D20 =+10.6° (3% in CHCl3).

1. customthe toluene product phase is removed
2. extractionthe aqueous phase is re-extracted twice with 250 ml of toluene
3. washThe toluene phases are washed with sodium chloride solution and with water
4. concentrationconcentrated by evaporation
5. customOrange-red oil, [α]D20 =+10.6° (3% in CHCl3)