反应详情

温度

0 °C

3-[(N-Benzyloxycarbonyl-N-ethyl-amino)-methyl]-4-bromo-benzoic acid ethyl ester (3.62 g, 7.2 mmol) was dissolved in MeOH (40 mL) and cooled to 0° C. 1N Aqueous LiOH (22 mL, 22 mmol) was added, and the reaction was stirred at room temperature for 3 hours. The mixture was quenched with 1N aqueous HCl (22 mL) and extracted three times with EtOAc. The combined organic layers were washed with brine, dried, and concentrated to give 3-[(N-benzyloxycarbonyl-N-ethyl-amino)-methyl]-4-bromo-benzoic acid, which was combined with the hydrolyzed product isolated in step 5.

1. customThe mixture was quenched with 1N aqueous HCl (22 mL)
2. extractionextracted three times with EtOAc
3. washThe combined organic layers were washed with brine
4. customdried
5. concentrationconcentrated