Hydrochloric Acid → HCID 22851704, compound

HRID 55461Notes

Reaction equation

HRID 55461 reaction equation
[ClH:1].[NH2:2][C@H:3]1[C@H:8]([C:9]([OH:11])=[O:10])[C@@H:7]([CH3:12])[O:6][C:4]1=[O:5].Cl.[CH3:14]O>>[ClH:1].[NH2:2][C@H:3]1[C@H:8]([C:9]([O:11][CH3:14])=[O:10])[C@@H:7]([CH3:12])[O:6][C:4]1=[O:5]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 22851700HCID 22851700, compound

Product 1

HCID 22851704HCID 22851704, compound

Procedure

19.56 g of 2(S)-amino-3(S)-carboxy-4(R)-pentanolide hydrochloride are suspended in methanol, the whole is gassed with hydrogen chloride for 15 minutes and stirred overnight at room temperature. The solvent is distilled off in a rotary evaporator and the residue is crystallised from chloroform: [α]D20 =-27.3° (1% in DMSO), m.p. 170°-172° C.

Workup

  1. distillationThe solvent is distilled off in a rotary evaporator
  2. customthe residue is crystallised from chloroform
  3. custom[α]D20 =-27.3° (1% in DMSO), m.p. 170°-172° C.

Sources & evidence

ORD record
ord-e278c8e7ad5243eb94ce27b1f2d64693
Source dataset
uspto-grants-1997_04
Patent number
US05625059

Reaction notes

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