Methyl 2-(5-bromopyridin-3-yl)acetate → [5-(2-Formyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid methyl ester

HRID 554622Notes

Reaction equation

HRID 554622 reaction equation
CC1(C)C(C)(C)OB([C:9]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][C:10]=2[CH:11]=[O:12])O1.[CH3:22][O:23][C:24](=[O:33])[CH2:25][C:26]1[CH:27]=[N:28][CH:29]=[C:30](Br)[CH:31]=1>>[CH3:22][O:23][C:24](=[O:33])[CH2:25][C:26]1[CH:27]=[N:28][CH:29]=[C:30]([C:9]2[CH:16]=[CH:15][C:14]([C:17]([F:18])([F:19])[F:20])=[CH:13][C:10]=2[CH:11]=[O:12])[CH:31]=1

Participants

3

Reactant 2

HCID 23398394Methyl 2-(5-bromopyridin-3-yl)acetateHCID 866405342-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzaldehyde

Product 1

HCID 86640539[5-(2-Formyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid methyl ester

Procedure

2-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzaldehyde and (5-bromo-pyridin-3-yl)-acetic acid methyl ester were reacted as described in Example 8, Step 4 to provide [5-(2-formyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid methyl ester.

Sources & evidence

ORD record
ord-3dad0b261ff64a65b904de5fdf7699bf
Source dataset
uspto-grants-2011_11
Patent number
US08049015B2

Reaction notes

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