Cyclopropanecarbonyl chloride → HCID 67212467, compound

HRID 554630Notes

Reaction equation

[CH2:1]([NH:8][CH2:9][C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:11]=1[Br:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:21]1([C:24](Cl)=[O:25])[CH2:23][CH2:22]1>>[CH2:1]([N:8]([CH2:9][C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:17])[F:18])[CH:13]=[CH:12][C:11]=1[Br:20])[C:24]([CH:21]1[CH2:23][CH2:22]1)=[O:25])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 67212329HCID 67212329, compound

Product 1

HCID 67212467HCID 67212467, compound

Procedure

Benzyl-(2-bromo-5-trifluoromethyl-benzyl)-amine and cyclopropanecarbonyl chloride were reacted as described in Example 11, Step 2 to provide cyclopropanecarboxylic acid benzyl-(2-bromo-5-trifluoromethyl-benzyl)-amide.

Sources & evidence

ORD record: ord-c810c869967c45838deb31614765ef33
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08049015B2

Reaction notes

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