Cyclopropanecarboxylic acid → (5-{2-[(N-Cyclopropanecarbonyl-N-ethyl-amino)-methyl]-4fluoro-phenyl}-pyridin-3-yl)-acetic acid ethyl ester

HRID 554638Notes

Reaction equation

HRID 554638 reaction equation
[CH2:1]([O:3][C:4](=[O:23])[CH2:5][C:6]1[CH:7]=[N:8][CH:9]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][C:13]=2[CH2:19][NH:20][CH2:21][CH3:22])[CH:11]=1)[CH3:2].[CH:24]1([C:27](O)=[O:28])[CH2:26][CH2:25]1>>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][C:6]1[CH:7]=[N:8][CH:9]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][C:13]=2[CH2:19][N:20]([C:27]([CH:24]2[CH2:26][CH2:25]2)=[O:28])[CH2:21][CH3:22])[CH:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 15655Cyclopropanecarboxylic acidHCID 58565094[5-(2-Ethylaminomethyl-4-fluoro-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

Product 1

HCID 58565012(5-{2-[(N-Cyclopropanecarbonyl-N-ethyl-amino)-methyl]-4fluoro-phenyl}-pyridin-3-yl)-acetic acid ethyl ester

Procedure

[5-(2-Ethylaminomethyl-4-fluoro-phenyl)-pyridin-3-yl]-acetic acid ethyl ester and cyclopropanecarboxylic acid were reacted as described in Example 8, Step 6 to provide (5-{2-[(N-cyclopropanecarbonyl-N-ethyl-amino)-methyl]-4-fluoro-phenyl}-pyridin-3-yl)-acetic acid ethyl ester.

Sources & evidence

ORD record
ord-683f2bc3189c481b8da77fe66dd7a668
Source dataset
uspto-grants-2011_11
Patent number
US08049015B2

Reaction notes

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