Benzenepropanoic acid → HCID 67212617, compound

HRID 554642Notes

Reaction equation

HRID 554642 reaction equation
Cl.Cl.[CH2:3]([O:5][C:6](=[O:28])[CH2:7][C:8]1[CH:9]=[N:10][CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:15]=2[CH2:24][NH:25][CH2:26][CH3:27])[CH:13]=1)[CH3:4].[C:29]([OH:39])(=O)[CH2:30][CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[CH2:3]([O:5][C:6](=[O:28])[CH2:7][C:8]1[CH:9]=[N:10][CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:22])([F:21])[F:23])=[CH:16][C:15]=2[CH2:24][N:25]([CH2:26][CH3:27])[C:29](=[O:39])[CH2:30][CH2:31][C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH:13]=1)[CH3:4]

Participants

3

Reactant 2

HCID 107Benzenepropanoic acidHCID 131729247[5-(2-Ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester, dihydrochloride

Product 1

HCID 67212617HCID 67212617, compound

Procedure

[5-(2-Ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester, dihydrochloride and hydrocinnamic acid were reacted as described in Example 8, Step 6 to provide [5-(2-{[N-ethyl-N-(3-phenyl-propionyl)-amino]-methyl}-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester.

Sources & evidence

ORD record
ord-854aa5295c554c488941a7b97b4d0ca1
Source dataset
uspto-grants-2011_11
Patent number
US08049015B2

Reaction notes

Loading…