2-Pyrazinecarboxylic acid → [5-(2-{[N-ethyl-N-(pyrazine-2-carbonyl)-amino]-methyl}-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

Participants

Role	Name	HCID	Charge
Reactant	2-Pyrazinecarboxylic acid	HCID 1047	—
Reactant	[5-(2-Ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester, dihydrochloride	HCID 131729247	—
Product	[5-(2-{[N-ethyl-N-(pyrazine-2-carbonyl)-amino]-methyl}-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester	HCID 67212438	—

Reaction Steps

[5-(2-Ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester, dihydrochloride and pyrazinecarboxylic acid were reacted as described in Example 8, Step 6 to provide [5-(2-{[N-ethyl-N-(pyrazine-2-carbonyl)-amino]-methyl}-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08049015B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-80b6ff7b116a465fbd1c01f8f4c59fdf
Source note	uspto-grants-2011_11