2-Pyrazinecarboxylic acid → [5-(2-{[N-ethyl-N-(pyrazine-2-carbonyl)-amino]-methyl}-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

HRID 554660Notes

Reaction equation

HRID 554660 reaction equation
Cl.Cl.[CH2:3]([O:5][C:6](=[O:28])[CH2:7][C:8]1[CH:9]=[N:10][CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:15]=2[CH2:24][NH:25][CH2:26][CH3:27])[CH:13]=1)[CH3:4].[N:29]1[CH:34]=[CH:33][N:32]=[CH:31][C:30]=1[C:35]([OH:37])=O>>[CH2:3]([O:5][C:6](=[O:28])[CH2:7][C:8]1[CH:9]=[N:10][CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:22])([F:21])[F:23])=[CH:16][C:15]=2[CH2:24][N:25]([CH2:26][CH3:27])[C:35]([C:30]2[CH:31]=[N:32][CH:33]=[CH:34][N:29]=2)=[O:37])[CH:13]=1)[CH3:4]

Participants

3

Reactant 2

HCID 10472-Pyrazinecarboxylic acidHCID 131729247[5-(2-Ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester, dihydrochloride

Product 1

HCID 67212438[5-(2-{[N-ethyl-N-(pyrazine-2-carbonyl)-amino]-methyl}-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

Procedure

[5-(2-Ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester, dihydrochloride and pyrazinecarboxylic acid were reacted as described in Example 8, Step 6 to provide [5-(2-{[N-ethyl-N-(pyrazine-2-carbonyl)-amino]-methyl}-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester.

Sources & evidence

ORD record
ord-80b6ff7b116a465fbd1c01f8f4c59fdf
Source dataset
uspto-grants-2011_11
Patent number
US08049015B2

Reaction notes

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