Ethyl isocyanate → HCID 60969782, compound

HRID 554758Notes

Reaction equation

HRID 554758 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([S:9]([NH2:12])(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[Cl:8].[CH2:13]([N:15]=[C:16]=[O:17])[CH3:14]>O1CCCC1>[Cl:8][C:7]1[CH:6]=[CH:5][C:4]([S:9]([NH2:12])(=[O:11])=[O:10])=[CH:3][C:2]=1[NH:1][C:16]([NH:15][CH2:13][CH3:14])=[O:17]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 957943-Amino-4-chlorobenzenesulphonamide

Product 1

HCID 60969782HCID 60969782, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To 3-amino-4-chlorobenzenesulfonamide (420 mg) in tetrahydrofuran (2 ml) solution, ethylisocyanate (180 μl) was added and the mixture was stirred under heating and reflux for 15 hours. The reaction solution was concentrated, then the residue was recrystallized from chloroform/methanol to obtain the title compound as a crude product (550 mg).

Workup

  1. temperatureunder heating
  2. temperaturereflux for 15 hours
  3. concentrationThe reaction solution was concentrated
  4. customthe residue was recrystallized from chloroform/methanol

Sources & evidence

ORD record
ord-cef6fe54b21f41878aeb11ea3250ed2f
Source dataset
uspto-grants-2011_11
Patent number
US08049006B2

Reaction notes

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