HRID554800

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2725036

tert-Butyl glycinate--hydrogen chloride (1/1)

C6H14ClNO2

HCID7022311

未命名化合物

结构：CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)NCC(=O)OC(C)(C)C

HCID76588771

未命名化合物

PRODUCTS

生成物

结构：CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)N[C@@H](CC(C)C)C(=O)O

HCID57670985

未命名化合物

PROCEDURE

实验过程

Instead of the starting material compound of Example 220, that is, the glycine tert-butyl ester hydrochloride, L-leucine tert-butyl ester was used for the similar procedure as in Example 220 and Example 245 to obtain the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9e6edd8f5e5a41a6a7e45c8056a6e348
来源数据集: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08049006B2
来源说明: uspto-grants-2011_11

反应 SMILES

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][CH:19]([CH2:31][CH3:32])[C:20]([NH:22][CH2:23][C:24]([O:26]C(C)(C)C)=[O:25])=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1.Cl.[C:38](OC(=O)CN)([CH3:41])([CH3:40])[CH3:39].C(OC(=O)[C@H](CC(C)C)N)(C)(C)C>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][C@H:19]([CH2:31][CH3:32])[C:20]([NH:22][C@@H:23]([CH2:39][CH:38]([CH3:41])[CH3:40])[C:24]([OH:26])=[O:25])=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1