Glycine tert-butyl ester hydrochloride → (2s)-2-{[(2r)-2-({[6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}-4-methylpentanoic acid

Participants

Role	Name	HCID	Charge
Reactant	Glycine tert-butyl ester hydrochloride	HCID 2725036	—
Reactant	tert-butyl (2S)-2-amino-4-methylpentanoate	HCID 7022311	—
Reactant	Tert-butyl {[2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}acetate	HCID 76588771	—
Product	(2s)-2-{[(2r)-2-({[6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}-4-methylpentanoic acid	HCID 57670985	—

Reaction Steps

Instead of the starting material compound of Example 220, that is, the glycine tert-butyl ester hydrochloride, L-leucine tert-butyl ester was used for the similar procedure as in Example 220 and Example 245 to obtain the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08049006B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-9e6edd8f5e5a41a6a7e45c8056a6e348
Source note	uspto-grants-2011_11