Bromobenzene → HCID 66943785, compound

HRID 554832Notes

Reaction equation

HRID 554832 reaction equation
C1([C:7]2[S:8](=[O:16])[C:9]3[N:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:15]=2)C=CC=CC=1.C1(Br)C=CC=CC=1>>[N:15]1[C:10]2[CH:11]=[CH:12][CH:13]=[N:14][C:9]=2[S:8](=[O:16])[CH:7]=1

Participants

3

Reactant 2

HCID 7961BromobenzeneHCID 67459179HCID 67459179, compound

Product 1

HCID 66943785HCID 66943785, compound

Procedure

In Scheme 6, Step A, a phenyl thiazolo-pyridinone of formula (22) is coupled with a phenyl bromide of formula (25a) or (25b) to give a thiazolo-pyridinone of formula (19) or formula (I). The reaction takes place in an inert solvent such as THF, or preferably dioxane with an inorganic base added, such as cesium carbonate. A copper catalyst is used, such as copper (I) iodide in the presence of sym-dimethylethylene diamine. The reaction is heated at a temperature of about 70° C. to the reflux temperature of the solvent.

Sources & evidence

ORD record
ord-f63522cda6d94b4f93f637e03ee6c4da
Source dataset
uspto-grants-2011_11
Patent number
US08049013B2

Reaction notes

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