Ethyl 2-(3-(2-(4-fluorobenzylamino)-2-oxoethyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate → 4-Methyl-2-(3-(2-(methylamino)-2-oxoethyl)-2-oxoimidazolidin-1-yl)thiazole-5-carboxylic acid

HRID 554894Notes

Reaction equation

HRID 554894 reaction equation
FC1C=CC([CH2:6][NH:7][C:8](=[O:27])[CH2:9][N:10]2[CH2:14][CH2:13][N:12]([C:15]3[S:16][C:17]([C:21]([O:23]CC)=[O:22])=[C:18]([CH3:20])[N:19]=3)[C:11]2=[O:26])=CC=1.CC1N=C(N2CCN(CC(NC)=O)C2=O)SC=1C(OCC)=O>>[CH3:20][C:18]1[N:19]=[C:15]([N:12]2[CH2:13][CH2:14][N:10]([CH2:9][C:8]([NH:7][CH3:6])=[O:27])[C:11]2=[O:26])[S:16][C:17]=1[C:21]([OH:23])=[O:22]

Participants

3

Reactant 2

HCID 57919793Ethyl 2-(3-(2-(4-fluorobenzylamino)-2-oxoethyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylateHCID 57919879Ethyl 4-methyl-2-(3-(2-(methylamino)-2-oxoethyl)-2-oxoimidazolidin-1-yl)thiazole-5-carboxylate

Product 1

HCID 579199524-Methyl-2-(3-(2-(methylamino)-2-oxoethyl)-2-oxoimidazolidin-1-yl)thiazole-5-carboxylic acid

Procedure

Following the procedure as described in Preparation 9, making variations as required to replace ethyl 2-(3-(2-(4-fluorobenzylamino)-2-oxoethyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate with ethyl 4-methyl-2-(3-(2-(methylamino)-2-oxoethyl)-2-oxoimidazolidin-1-yl)thiazole-5-carboxylate, the crude title compound was obtained.

Workup

  1. customas described in Preparation 9

Sources & evidence

ORD record
ord-43be7a7ca8344eb68bcabc84989f1b6d
Source dataset
uspto-grants-2011_11
Patent number
US08049016B2

Reaction notes

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